There are two studies that included 319 and 344 infants of people who had taken etanercept during pregnancy that reported a higher rate of birth defects compared to the infants of individuals with autoimmune diseases who did not take a TNF inhibitor during pregnancy. At least six smaller studies (each looking at fewer than 100 individuals taking etanercept in the first trimester) have not found an increased chance for a pattern of birth defects. The authors of a study published in 2018 stated that there was no increase in birth defects compared to people not using a TNF inhibitor. Most studies on etanercept use during pregnancy do not suggest an increase in the chance of birth defects above the background risk. About one third of these people continued to take the medication throughout pregnancy.ĭoes taking etanercept increase the chance of birth defects?Įvery pregnancy starts out with a 3-5% chance of having a birth defect. A study that surveyed rheumatologists (doctors that are trained to diagnose and treat pain in the bones, joints, and muscles) reported no increase in miscarriage in 417 people exposed to etanercept or another TNF inhibitor during pregnancy. A study published in 2017 found that 337 people treated with etanercept during their pregnancy did not have a higher rate of miscarriage compared to similar groups of people who were not treated with etanercept in their pregnancy. Etanercept is being studied to see if it may be used with other therapies to improve the success rates of certain fertility treatments in some people.ĭoes taking etanercept increase the chance for miscarriage? There are no reports linking etanercept to trouble getting pregnant. Can it make it harder for me to get pregnant? In healthy adults, it takes about three to four weeks after the last injection of etanercept, on average, for most of the medication to be gone from the body. People eliminate medications at different rates. I am taking etanercept, but I would like to stop taking it before becoming pregnant. Your healthcare providers can talk with you about the benefits of treating your condition and the risks of untreated illness during pregnancy. However, it is important to talk with your healthcare providers before making any changes to how you take this medication. Sometimes when people find out they are pregnant, they think about changing how they take their medication, or stopping their medication altogether. Etanercept is sold under the brand name Enbrel®. TNF is a substance in the body that causes inflammation in the joints, spine, and skin. Įtanercept is called a tumor necrosis factor (TNF) inhibitor because it binds and blocks TNF. For more information, please see the MotherToBaby fact sheets on rheumatoid arthritis at, ankylosing spondylitis at, and psoriasis/psoriatic arthritis at. This information should not take the place of medical care and advice from your healthcare provider.Įtanercept is a prescription medication used to treat some autoimmune diseases such as rheumatoid arthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, and juvenile rheumatoid arthritis. This sheet is about exposure to etanercept in pregnancy and while breastfeeding.
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